Coronavirus infects the brain. Two new studies: “Loss of smell between symptoms, attack on the nervous system”

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The coronavirus it would directly infect the central nervous system. The hypothesis is contained in two scientific articles, the first, published by Chinese researchers on the Journal of Clinical Virology analyzed the data obtained over time on coronaviruses other than Sars-CoV-2; the second, published almost simultaneously on the Chemical Neuroscience, proposes mechanisms of action capable of explaining this potential ability of the virus to infect the central nervous system. The loss of smell turned out to be one of the various symptoms of Covid-19. Ignored at the beginning of the disease, it has now been ascertained in several countries affected by the coronavirus and could be explained by the ability of the virus to infect the central nervous system of patients, particularly in the area of brain deputy for olfactory functions.

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The team led by Yan-Chao Li of the University of Jilin, China, analyzed samples taken in the early 2000s on victims of Sars-CoV-1, coronavirus cousin than the current one. These samples, the authors explain, “showed the presence of virus particles in the brain, found almost exclusively in neurons.” Other studies, conducted on transgenic mice, modified to be sensitive to coronaviruses that affect humans, have shown that Sars-CoV-1 or Mers-CoV (virus responsible for an epidemic that hit the Middle East in 2012) « they can penetrate the brain, probably through the olfactory nerves, and spread rapidly to some specific areas of the brain, in particular the thalamus and cerebral cortex “.

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“The Chinese team article is very interesting because it is based on clinical observations, interpreted using a summary of what we know about coronaviruses,” explained biologist Christine Prat, of the European Virus Archive Global consortium. «However, much remains to be understood about the impact that some have viruses can have on the central nervous system, which is a very particular area: the immune system cannot work there as in the rest of the body because it must fight against infection by avoiding destroying neuronal cells, which do not renew themselves or do very little ».

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Last updated: 16:56 © RESERVED REPRODUCTION



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